This activity is jointly provided by Global Education Group and PlatformQ Health Education, LLC, in collaboration with Kidney Disease: Improving Global Outcomes (KDIGO).

ACKNOWLEDGEMENT

This activity is supported by an independent educational grant from Boehringer Ingelheim Pharmaceuticals, Inc. and Eli Lilly and Company.

DATE OF LIVE ACTIVITY

This activity was released on December 5, 2022 and is valid for 12 months. Requests for credit must be made no later than December 5, 2023.

TARGET AUDIENCE

The educational design of this activity addresses the needs of nephrologists, cardiologists, endocrinologists, internal medicine physicians, primary care physicians, nurse practitioners and physician assistants. Secondary audiences include clinical pharmacists, nurses, and other clinicians who care for patients who are at risk for CKD or at high risk of progression.

STATEMENT OF NEED/PROGRAM OVERVIEW

Recently, SGLT2 inhibitors have been shown to slow the progression of chronic kidney disease (CKD), independent of whether the patient has diabetes. However, CKD is a silently progressive disease and most patients do not have their kidney function evaluated regularly, leaving many patients with CKD that is not recognized until it is in an advanced stage.

Join a panel of expert clinicians to explore strategies to recognize predisposing risk factors for CKD and improve the timeliness of referrals to specialists. Panelists will review the most recent data on SGLT2 inhibitors in advanced kidney disease and demonstrate how to apply that evidence in a variety of patient scenarios. Clinicians will learn about dosage and titration, use of SGLT2 inhibitors with RAS inhibition, and impacts on blood pressure, intraglomerular pressure, and hyperfiltration.

EDUCATIONAL OBJECTIVES

After completing this activity, the participant should be better able to:

• Develop strategies for multidisciplinary care team members to assess kidney function in high-risk people because of race/ethnicity and/or the presence of predisposing conditions
• Summarize the evidence supporting the impact of SGLT2 inhibitors on the progression of CKD, including conversion to end-stage renal disease (ESRD), in patients with advanced CKD independent of impacts on co-existing conditions
• Describe the mechanisms by which SGLT2 inhibitors slow down progression of CKD to ESRD, including impacts on blood pressure, intraglomerular pressure, and hyperfiltration

PHYSICIAN ACCREDITATION STATEMENT

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Global Education Group (Global) and PlatformQ Health Education, LLC. Global is accredited by the ACCME to provide continuing medical education for physicians.

PHYSICIAN CREDIT DESIGNATION

Global Education Group designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

ESTIMATED TIME TO COMPLETE

This activity should take approximately 1 hour to complete.

INSTRUCTIONS TO RECEIVE CREDIT

In order to receive credit for this activity, the participant must (1) read the target audience, learning objectives, and disclosure statements, (2) complete the educational activity online, and (3) complete the post-test and activity evaluation. To receive AMA PRA Category 1 Credits™, participants must receive a minimum score of 70% on the post-test.

HARDWARE/SOFTWARE REQUIREMENTS

Participants will need a computer with a recent version of Adobe Flash installed, as well as an internet connection sufficient for streaming media.

FEE INFORMATION & REFUND/CANCELLATION POLICY

There is no fee for this educational activity.

DISCLOSURE OF CONFLICTS OF INTEREST

Global Education Group (Global) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous. All persons in a position to control the content of an accredited continuing education program provided by Global are required to disclose all financial relationships with any ineligible company within the past 24 months to Global. All financial relationships reported are identified as relevant and mitigated by Global in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by Global to assure objectivity and that the activity is free of commercial bias.

All relevant financial relationships have been mitigated.

The faculty have the following relevant financial relationships with ineligible companies:

Name of Faculty or Presenter	Reported Financial Relationship
Ramy M. Hanna, MD, FASN, FACP, FNKF Associate Professor of Medicine – I Fellowship Program Director University of California, Irvine	Contracted Research: Alexion, Appelis, Otsuka, Remegen, Roche Speakers’ Bureau: Alexion, Aurinia, AstraZeneca, GSK, Otsuka
Silvio E. Inzucchi, MD Professor of Medicine Clinical Chief, Endocrinology Medical Director, Yale Diabetes Center Yale School of Medicine Yale New Haven Hospital	Consulting Fee (e.g., Advisory Board): Abbott, AstraZeneca, Bayer, Boehringer Ingelheim/Lilly, Esperion, Lexicon, Merck/Pfizer, Novo Nordisk, VTV Therapeutics Honoraria: Abbott, AstraZeneca, Bayer, Boehringer Ingelheim/Lilly, Esperion, Lexicon, Merck/Pfizer, Novo Nordisk, VTV Therapeutics
Meg J. Jardine, MD, PhD, FRACP Professor University of Sydney	Consulting Fee (e.g., Advisory Board): Akebia, AstraZeneca, Baxter, Bayer, Boehringer Ingelheim, Chinook Therapeutics, CSL Behring, Janssen, Vifor Contracted Research: Amgen, Baxter, CSL, Dimerix, Eli Lilly, Gambro, MSD Honoraria: Amgen, AstraZeneca, Janssen, Merck, MSD, Roche, Vifor

The planners and managers have the following relevant financial relationships with ineligible companies:

Name of Planner	Reported Financial Relationship
Lindsay Borvansky	Nothing to disclose
Andrea Funk	Nothing to disclose
Liddy Knight	Nothing to disclose
Ashley Cann	Nothing to disclose
Lauren Sinclair	Nothing to disclose
Jaimee Harris-Gold	Nothing to disclose
Terry Glauser	Nothing to disclose

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Global Education Group (Global) and PlatformQ Health Education, LLC do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

DISCLAIMER:

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed in this activity should not be used by clinicians without evaluation of patient conditions and possible contraindications on dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

CONTACT INFORMATION

Accreditation Support:

For information about the accreditation of this program, please contact Global at 303-395-1782 or cme@globaleducationgroup.com

Technical Support:

For any technical issues or issues with your CME Certificate, please contact ClinicalSeriesLive or CardioCareLive at 877-394-1306 or at Support@ClinicalSeriesLive.com or Support@CardioCareLive.com.